Scientist I/II - Oligonucleotide Chemistry

Research San Diego, California


Job Posting


Job Title:

Scientist, Oligonucleotide Chemistry


La Jolla, California

Position type:

Full Time

Required education:

Ph.D., MS, or BS in Organic Chemistry/Chemical Biology

Area(s) of expertise desired:

Oligonucleotide Synthesis, ASO, siRNA

Company Description

Avidity Biosciences is pioneering a new class of oligonucleotide-based therapies called AOCs designed to overcome the current limitations of oligonucleotide therapies to treat a wide range of serious diseases. We utilize our proprietary AOC platform to design, engineer, and develop therapeutics that combine the tissue selectivity of monoclonal antibodies (mAbs) and the precision of oligonucleotide-based therapies to access previously undruggable tissue and cell types and more effectively target underlying genetic drivers of diseases. More information about Avidity Biosciences can be found on our website:

Job Summary

We are looking for a Scientist to join our team with strong oligonucleotide design, synthesis, and analysis skills. This is a full-time laboratory position, and the candidate is required to perform research in developing antibody oligonucleotide therapeutics. A researcher with hands-on experience with oligonucleotide synthesis and passionate for solving oligonucleotide delivery challenges is perfect for this role. The candidate is expected to play a key role in design, synthesis, and analysis of a variety of oligonucleotides and developing next-generation oligonucleotide delivery technologies. The candidate is a strong team player who involves in rigorous scientific discussions and communicates and collaborates in an interdisciplinary environment.

Primary responsibilities of this position will include

  • Synthesis and purification of oligonucleotides on milligram to gram scales in a timely fashion
  • Develop oligonucleotide synthesis, purification, and analytical methods for chemically modified oligonucleotides
  • Lead oligonucleotide design for research programs and oligonucleotide delivery
  • Manage all the equipment necessary for oligonucleotide synthesis, purification, and analysis
  • Collaborative research with other members of the chemistry and biology teams
  • Clearly communicate research results in both oral and written formats
  • Excellent organizational skills and ability to accomplish goals under strict timelines.


Qualifications, Required Experience & Skills

  • Ph.D. in Organic Chemistry/Chemical Biology or MS with 4+ years or BS with 8+ years of experience
  • A demonstrated record of oligonucleotide synthesis, purification, and analysis of oligonucleotides is necessary
  • Expertise in nucleoside chemistry, chemical modifications of oligonucleotides, and the delivery of oligonucleotides
  • Hands-on experience with Dr. Oligo, MerMade and AKTA Oligopilot oligonucleotide synthesizers
  • Proficient with chromatography techniques (ion exchange, size exclusion, hydrophobic interaction chromatography, etc.) using FPLCs, HPLCs, and LC/MS.
  • Strong scientific and analytical skills, ability to multitask efficiently, prioritize quickly and bring projects to a conclusion.
  • Proven ability to conduct self-directed research, troubleshooting, and to work effectively in a dynamic environment with a diverse team
  • Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary


Salary Range: $110,000 - $140,000