Senior Scientist, Chemistry

Research and Development La Jolla, California


We are building a state-of-the art oligonucleotide synthesis lab at Avidity Biosciences in La Jolla, California.  We are looking for candidates who can start the oligo synthesis lab. An independent researcher with hands on experience with oligonucleotide synthesis and passionate about solving oligonucleotide delivery challenges is perfect for this role. This is a hands-on position with responsibility for the design, synthesis, and analysis of oligonucleotides. The candidate is expected to start the oligonucleotide synthesis at Avidity including establishing the oligo synthesis lab and setting up synthesis, purification, and analytical method protocols. The candidate is expected to play a key role in developing next generation delivery technology and research programs. The candidate is a strong team player, who enjoys scientific discovery and has the ability to communicate and collaborate in an interdisciplinary environment.


  • Establish oligo synthesis lab to enable milligram to gram scale synthesis of complex oligonucleotides
    • Develop oligonucleotide synthesis, purification, and analytical methods
    • Manage all the equipment necessary for oligonucleotide synthesis, purification, and analysis
    • Collaborative research with other members of the chemistry and biology teams
    • Lead oligonucleotide design for research programs and oligonucleotide delivery

Qualifications, Required Experience & Skills:
• Ph.D. in organic chemistry and in depth oligonucleotide chemistry knowledge
• A strong record of oligonucleotide synthesis, purification, and analysis of oligonucleotides
• Expertise in nucleoside chemistry, chemical modifications of oligonucleotides and the delivery of oligonucleotides
• Hands on experience with AKTA Oligopilot and MerMade oligonucleotide synthesizers
• Strong scientific and analytical skills, ability to multitask efficiently, prioritize quickly and bring projects to conclusion.
• Proven ability to conduct self-directed research, troubleshooting, and to work effectively in a dynamic environment with a diverse team
• Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary

Ph.D. in organic chemistry
Oligonucleotide synthesis is a must and previous experience in biotech/pharma setting is highly desirable.