Senior Clinical Program Manager - Oncology
Description
Summary
The Senior Clinical Program Manager (Sr. CPM) is responsible for the strategic and operational leadership of one or more complex clinical studies. This role ensures clinical trials are executed on time, within budget, and in compliance with ICH GCP, regulatory requirements, and Arcus SOPs. The Sr. CPM performs all core responsibilities of the Clinical Program Manager (CPM), with expanded scope in strategic study oversight, vendor management, leadership, and program-level contribution. The Sr. CPM may mentor junior staff and serve as a subject matter expert within Clinical Operations.
Candidates located in the Bay Area are expected to work in a hybrid model with regular in-office presence (2-3 days per week). Remote candidates within the U.S. will be considered.
Responsibilities
Strategic & Operational Study Leadership
- Lead one or more complex or global clinical studies, providing strategic input into program planning and operational strategy.
- Oversee day-to-day study management activities from start-up through close-out.
- Anticipate operational risks and develop proactive mitigation and contingency plans.
- Ensure consistency, quality, and inspection readiness across studies.
Cross-Functional & Study Team Leadership
- Lead cross-functional study teams to plan, implement, and execute clinical trials within agreed timeline, budget, and quality standards.
- Serve as the primary operational contact for functional area representatives, CROs, service providers, and vendors.
- Facilitate operational activities for Phases I–IV clinical trials, including submissions, study plans, study tools, and Investigator Meetings.
Vendor and CRO Oversight
- Manage key vendors; define, monitor, and act on performance metrics and KPIs.
- Oversee CROs and service providers, including selection, study‑specific training, and ongoing performance oversight.
- Participate in outsourcing activities and contribute to service provider evaluation.
Documentation, Quality, & Compliance
- Ensure compliance with ICH GCP, applicable regulations, protocols, and company SOPs.
- Contribute to or review study-related documents such as protocols, IBs, CRFs, informed consent forms, and study plans.
- Participate in and respond to Quality Assurance audits and regulatory inspections.
- Support inspection readiness activities at the study and program level.
Study Tracking, Budget, & Reporting
- Establish and track study milestones; ensure accurate reporting of study status and metrics.
- Prepare and manage study budgets and timelines, ensuring financial accountability and forecasting accuracy.
Process Improvement & Leadership Contributions
- Recommend and implement process improvements and innovations to improve study quality and operational efficiency.
- Serve as a subject matter expert for clinical operations processes, tools, and systems.
- Mentor and develop junior staff, contributing to competency growth across the organization.
- Build and maintain strong internal and external relationships to support clinical program success.
Qualifications
- Bachelor’s degree, preferably in a scientific field.
- 8+ years of industry experience, with 7+ years of global study management experience at a Sponsor or CRO.
- Demonstrated experience leading oncology, inflammation, or immunology clinical studies.
- Strong leadership skills with proven experience managing cross-functional teams and vendors.
- Excellent written and verbal communication skills.
- Strong analytical, organizational, and problem-solving abilities.
- Ability to manage multiple priorities in a dynamic environment.
- Self-motivated, collaborative, and adaptable.
- Proficiency with Microsoft Office and clinical trial systems (EDC, IRT, CTMS, eTMF, etc.).
- Ability and willingness to travel 10–20% domestically and internationally.
This role can be based at our Hayward or Brisbane, CA location (preferred) or can be remote based. The anticipated salary range for fully qualified candidates applying for this position is $190,000 - $200,000 USD annually. This salary range is an estimate of what we reasonably expect to pay for this posted position. The actual salary may vary based on various factors including, without limitation, individual education, experience, tenure, skills and abilities, internal equity and alignment with market data. In addition to a competitive market-based salary, Arcus offers the opportunity to participate in stock programs, a performance-based bonus, and a comprehensive benefits package. Additional information about our total rewards program can be found here: https://arcusbio.com/careers.
EOE
Arcus Biosciences is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Arcus is committed to the principle of equal employment opportunity for all employees and does not discriminate based on race, religion, color, sex, gender identify, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status or any other legally protected status. EOE/AA/Vets
Physical Requirements Office Setting
Must possess mobility to work in a standard office setting and use standard office equipment, including a computer; vision to read printed materials and a computer screen; and hearing and speech to communicate in person, before groups, and over the telephone. This is primarily a sedentary office classification although standing in work areas and walking between work areas may be required. Finger dexterity is needed to access, enter, and retrieve data using a computer keyboard, mouse, or calculator, and to operate standard office equipment. Positions in this classification occasionally bend, stoop, kneel, reach, push, and pull drawers open and closed to retrieve and file information. Employees must possess the ability to lift, carry, push, and pull materials and objects weighing up to 25 pounds.
#LI-JS1
#LI-Remote