Scientist, Translational Science (TS)
Description
Scientist, Translational Science (TS)
Arcus Biosciences is an exciting growth company founded on the vision of creating best-in-class cancer therapies. We are an oncology-focused biopharmaceutical company leveraging deep cross-discipline expertise to discover highly differentiated therapies and develop a broad portfolio of novel combinations addressing significant unmet needs.
Overall description:
This position in the Pharmacodynamics (PD) team offers a unique professional opportunity to gain in-depth exposure to industrial drug discovery and development from a proven research team. The PD group is focused on the development and execution of assays to evaluate engagement of our drugs and their biological effects in patient samples. Our role within the Translational Science (TS) department is a central element of our clinical research engine and we have a position available to work on-site at our headquarters in Hayward, CA.
The ideal candidate will have a working knowledge of immunology and prior technical experience with flow cytometry, ELISA, quantitative real-time PCR, and data analysis/visualization software. Familiarity with assay development/validation and clinical sample handling (particularly human blood) would be an advantage. Significant experience in multi-color flow cytometry assays and associated data analysis is highly preferred. This position will require a candidate with very strong organizational skills and attention to detail, ability to plan and execute experiments independently with direction, coupled with an aptitude and enthusiasm for collaboration, maintaining high quality data, and managing the integrity of our complex clinical trial datasets and sample databases.
Responsibilities may include, but are not limited to:
- Planning and executing pharmacodynamic and biomarker assays for clinical patient blood samples, including in vitro immunoassays, biochemical assays, and molecular assays (ie: flow cytometry, ELISA, enzymatic inhibition assays, RT-qPCR)
- Development and validation of new assays as molecules move towards first in human (FIH) studies
- Handling of biological samples and familiarity with sample processing procedures, including isolation of peripheral blood mononuclear cells, serum and plasma, or nucleic acids from patient blood samples
- Working with a team of PD scientists and research associates to ensure that all clinical samples are received and processed in a timely manner to ensure consistent delivery of high-quality data
- Participating in clinical sample database management, including accessioning and record-keeping pertaining to patient samples (advanced opportunities in database management and automation of laboratory processes available depending on aptitude and interest)
- Experiment design and planning with appropriate input and oversight from manager/leadership with independent analysis of experimental data
- Summarizing experimental data and delivering regular research updates during project team meetings
Qualifications:
- PhD degree with 0+ years of experience or MSc degree with 5+ years of experience in immunology, biology, biochemistry, molecular biology or related field, with minimum 3+ years research experience, preferably in an industry setting. Title and salary are commensurate with experience.
- Proven laboratory and analytical skills including experience with immunoassay techniques, particularly flow cytometry
- Exceptional attention to detail and organizational skills
- Willingness to learn and adapt quickly in a fast-paced environment to deliver on time-sensitive objectives
- An aptitude for independent critical thinking, process optimization, and assay development/validation
This role is based at our Hayward, CA location. The anticipated salary range for fully qualified candidates applying for this position is $125,000 - $165,000 USD annually. This salary range is an estimate of what we reasonably expect to pay for this posted position. The actual salary may vary based on various factors including, without limitation, individual education, experience, tenure, skills and abilities, internal equity and alignment with market data. In addition to a competitive market-based salary, Arcus offers the opportunity to participate in stock programs, a performance-based bonus, and a comprehensive benefits package. Additional information about our total rewards program can be found here: https://arcusbio.com/careers.
EOE
Arcus Biosciences is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Arcus is committed to the principle of equal employment opportunity for all employees and does not discriminate based on race, religion, color, sex, gender identify, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status or any other legally protected status. EOE/AA/Vets
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