Scientist, Neuroscience Discovery
Uniquely positioned to enhance quality of life in aging, at Alkahest, we are pioneering science that is rapidly being translated to the clinic. Our approaches utilize in vivo, in vitro, proteomic, and molecular techniques to identify new therapeutics and apply them to patients.
We are seeking a highly motivated and driven Scientist who will be key in establishing and executing in vivo studies to advance multiple programs in our therapeutic pipeline. The position focus is primarily on cognition and disorders of the nervous system. The scientist will be responsible for designing in vivo experiments and developing novel assays including behavioral, histological, and biochemical endpoints to test candidate target pathways. The scientist will lead and hire a team of motivated research associates in carrying out the projects. The role is critical in driving the scientific team in advancing our therapeutic understandings, and will involve establishing, validating, and implementing methodologies in the lab. The role requires dedication, flexibility, drive, ability to thrive in a fast-paced environment, excellent communication and organization, and interaction with a team of scientists and research associates to drive multiple projects in parallel.
Alkahest offers a competitive compensation and benefits package, annual bonus potential, stock options, opportunities for career growth and development, and a work environment that is collaborative, collegial and lots of fun.
Specific responsibilities include, but are not limited to:
- Designing, performing, and analyzing rodent in vivo experiments
- Designing, analyzing, and managing in vitroexperiments
- Establishing and optimizing standard and novel behavioral assays
- Administering test agent via multiple routes (IV, PO, IP, SC)
- Performing histology, immunohistochemistry, microscopy, and image analysis
- Performing biochemical and molecular analysis (i.e. RT-qPCR, Western blot, ELISA)
- Developing and optimizing assays for elucidation of target engagement and mechanism of action investigation
- Maintaining familiarity with current scientific literature
- Investigating and developing new methods and technologies for project advancement
- Writing scientific reports
- Managing a team of research associates conducting in vivo work
- Interfacing on a regular basis with lead scientific staff to organize, coordinate, schedule, and execute experimental work.
- PhD degree from an accredited college/university in a field related to biomedical research, cell biology, molecular biology, biochemistry, or neuroscience; post-doctoral experience preferred
- Minimum of 8 years of progressively advancing academic and/or industry lab experience
- Experience with mouse handling and dosing is necessary
- Experience with behavior and cognitive assays is necessary
- Solid experience with immunohistochemistry and microscopy is necessary
- Experience with confocal microscopy and image analysis is critical
- Solid experience with qPCR, Elisa, IP, Western blot are required
- Ability to work collaboratively and excellent interpersonal, verbal, and written communication skills
- Attention to detail and strong organizational skills