Research Associate I, Biology
MyoKardia is applying precision medicine where we feel it is needed most: altering the course of genetic cardiovascular disease. We are progressing our drug discovery projects towards current and novel targets implementing state of the art screening methodologies including the development of a panel of engineered human iPSC-CMs containing disease-causing mutations. Our mission is to identify the next generation of cardiovascular therapeutics by integrating clinical and molecular information based on the biological basis of disease.
We are seeking an enthusiastic, detail-orientated, and skilled Research Associate with an interest in discovery and development of novel therapies as well as iPSC technologies. The successful candidate will work both independently and collaboratively as part of the Cell Biology team.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
- Perform a diverse range of cell-based assays to characterize lead candidates for various therapeutic mechanisms.
- Expand and differentiate human iPSCs towards the cardiovascular lineage.
- Execute a range of experiments using molecular biology and cell biology techniques including nucleic acid and protein isolation, qPCR, virus preparation, and metabolic assays.
- Manage aspects of housekeeping for the cell culture lab, including preparing reagents, helping with room maintenance, ordering and restocking.
- Generate and update experimental protocols for all procedures.
- Be responsible for data collection, organization and record keeping. Present findings in internal panels and meetings.
- Collaborate with colleagues and team members to advance progress of projects.
- Other projects when assigned.
- BS or MS degree in Biology, Biochemistry, Physiology or related discipline.
- Minimum of 0-2 years of work experience in academic or industrial environment.
- Proficiency in data analysis and data sharing software.
- Self-motivated, enthusiastic, and passionate for cutting edge science and iPSC technologies.
- Practical experience of cell culture.
- Experience in iPSC culture and cardiac differentiation is preferred.
- Experience of molecular biology and automated cell analyses.
- Excellent written and interpersonal communication team.
- Ability to work productively in a collaborative, integrated and fast-paced environment.
- Familiarity with cellular electrophysiology advantageous, but non-essential.