Principal Scientist/Associate Director, Medicinal Chemistry

Medicinal Chemistry Cambridge, Massachusetts


Description

Epizyme, named a Fierce 15 company by Fierce Biotech, ranked #1 and #2 worldwide by The Scientist in "Best Places to Work Industry”, and most recently named Innovation All Star by the Boston Business Journal, has grown successfully since its founding in 2007 in Cambridge, MA. Epizyme is a clinical stage biopharmaceutical company creating targeted epigenetic therapeutics for patients with cancer. Our lead program, tazemetostat, is in Phase 2 development for the treatment of patients with non-Hodgkin lymphoma, and a Phase 2 adult and a Phase 1 pediatric study are planned in patients with a subset of genetically defined tumors including malignant rhabdoid tumors, epithelioid sarcomas, and synovial sarcomas.  Epizyme owns worldwide rights to tazemetostat outside of Japan, and has started a broad Phase 2 clinical development program. Epizyme has built a proprietary product platform that the company uses to create small molecule inhibitors of a 96-member class of enzymes known as histone methyltransferases, or HMTs. HMTs are part of the system of gene regulation, referred to as epigenetics, that controls gene expression. Genetic alterations can result in changes to the activity of HMTs, making them oncogenic (cancer-causing). We seek a top notch contributor to join our culture of transparency, intensity, scientific rigor, and fun!

 

The successful candidate will be responsible for independently developing and implementing medicinal chemistry strategies that effectively surmount complex research problems and facilitate the achievement of key corporate goals – on time and on budget.  Qualified candidates will be expected to work collaboratively and communicate well both within group and across group settings and will be proficient in data analysis and interpretation.

 

We are seeking a highly motivated Scientist for our Medicinal Chemistry group.

 

SUMMARY:

 

A Principal Scientist/Associate Director who will be the chemistry project leader for a new project and manage CRO-based chemists. The successful candidate will be responsible for independently developing and implementing medicinal chemistry strategies that effectively surmount complex research problems and facilitate the achievement of key corporate goals – on time and on budget.  Qualified candidates will be expected to work collaboratively and communicate well both within group and across group settings and will be proficient in data analysis and interpretation.

 

Responsibilities

 

  • Provide chemistry project leadership
  • Devise and implement medicinal chemistry strategies addressing critical project issues
  • Collaborate as part of an integrated, cross functional program team towards the advancement of high quality drug candidates into clinical development
  • Support patent filings
  • Manage outsourced FTE's
  • Influence strategic and tactical direction of the chemistry group
  • Responsible for communicating project updates to the management team

 

Requirements

 

  • Deep understanding of synthetic and medicinal chemistry, as evidenced by a record of achievement (publications, patents, etc.)
  • Proven track record for delivery of pre-clinical candidates
  • Previous project leadership and outsourcing experience a plus
  • An ideal candidate will also have had experience with structural based design and experience with novel technologies such as fragment based hit optimization
  • Excellent analytical, organizational and communication skills are essential

 

Education/Experience

 

  • PhD in Organic chemistry
  • >7 years’ pharmaceutical experience

 

 

 

Epizyme, Inc. is a vibrant, entrepreneurial EEO employer committed to a diverse and dynamic workplace.