Senior Director, Clinical Sciences
Description
Headquarters Location: South San Francisco, CA
Candidate Location: Hybrid
Travel Required: 5%
Reports To: Vice President, Clinical Development
Department: Clinical Development
Position Type: Full-time, Exempt
About CytomX Therapeutics:
CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel Probody® therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX has a broad pipeline, which comprises seven therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), T-cell engaging bispecific antibodies (“TCBs”), and immune modulators such as cytokines and checkpoint inhibitors (“CPIs”). Learn more at www.cytomX.com.
Who You Are and What You’ll Do:
You are passionate about life sciences and making a difference to cancer patients, their families, and healthcare providers. You will play a leading role in our Clinical Research team. The role will partner with the Clinical Development physicians to coordinate the activities of the clinical programs. The Senior Director, Clinical Sciences will lead early phase clinical development of oncology compounds from first-in-human studies through proof of concept. The Senior Director, Clinical Sciences will define, design, and execute early-phase clinical and translational projects as the initial strategy for drug development and provide subject matter expertise in clinical and translational trial science as well as the biology and treatment of cancer. This position will work closely with clinical project teams, marketing and business development as well as externally with regulatory bodies and service providers.
Job Responsibilities:
- Serve as an internal clinical expert in translational and clinical oncology
- Provide input to the Clinical Development team and investigate new indications for molecules in development
- Create clinical trial documents including clinical protocols, investigator brochures, DSURs and clinical modules of the IND
- Work closely with Clinical Operations to execute the clinical trial with high quality and according to timelines
- Perform ongoing review of clinical data, query generation/resolution and data analysis, including review of draft listings to support data cleaning and interpretation
- May serve as medical monitor for clinical trials and assist in resolving major issues that may affect the studies
- Provide medical input for the clinical database build, CRFs, monitoring plan, data management plan, and statistical analysis plan
- Present information internally and externally, anticipating and proactively managing problems across a broad spectrum of cross-functional teams
- Represent Clinical science function during CRO evaluation and selection and in the identification of principal investigators, and consultants
- Develop and maintain relationships with clinical trial investigators and therapeutic area key opinion leaders
- Lead cross-functional team to review study data (e.g. tables, listings and figures and emerging bioanalytical data) and development of CSRs, clinical presentations and publications
- Support other members of Clinical Development as required
- Participates as a standing member of multidiscipline Project Teams and -depending on experience- lead clinical sub-teams
Minimum Qualifications:
- Advanced degree (PhD, PharmD, MD) in a relevant scientific discipline with experience in drug development
- 8+ years direct relevant experience in clinical research management with previous experience as a clinical scientist or medical director, including: hands on experience with clinical operations, liaising with clinical trial teams and study investigators, and trial medical authoring, monitoring, and analyzing
- Experience in Oncology drug development and regulatory aspects throughout phases I-III
- Experience in analysis and interpretation of emerging clinical data, including use of software packages to analyze data
Preferred Qualifications:
- Subspecialty board eligibility/certification in Oncology and/or Hematology preferred
- Experience in translational medicine/early phase clinical trials is a plus
- Excellent written and oral communication skills and interpersonal skills
How You Will Work:
- Demonstrates collaboration and teamwork. Works well with others and understands that collaboration leads to better results.
- Possesses strong communication skills. Communicates clearly, concisely, and professionally. Listens actively to build understanding.
- Exhibits strong interpersonal skills and self-awareness. Builds and cultivates strong and enduring relationships with others. Acts with humility and understands own strengths and weaknesses.
- Shows continuous improvement and a commitment to self-management and development. Operates with a continuous improvement mindset and continuously seeks to expand own knowledge and capabilities.
- Demonstrates a patient focus. Puts the patient first in actions and decisions taken.
- Contributes to strategy and innovation. Contributes to or leads elevating and actionable strategies. Ideates and creates unique opportunities to advance the organization.
- Demonstrates leadership and a commitment to organizational values. Takes ownership and has a strong sense of personal accountability. Consistently achieves or exceeds goals and expectations. Puts significant emphasis on living / upholding company values.
- Demonstrates ability and commitment to building effective teams. Attracts, develops, and retains diverse top talent. Aligns, mobilizes, and engages others to achieve and sustain peak performance.
- Has a track record of driving vision and purpose in teams.
Compensation, Benefits, and So Much More
- The expected salary range for this role based on the primary location for this position in California is $250,000 - $311,000 per year. Offer amounts are determined by factors such as experience, qualifications, geographic location, and other job-related factors permitted by law.
- A great environment where we work collaboratively, leverage each other’s strengths, and work toward a shared vision with our common goals of doing the best thing for patients.
- A robust and enduring approach to your development and career growth fueled by a strong learning curriculum and career guidance that helps you understand how you can grow your career at CytomX.
- A robust and highly competitive total rewards program that helps you achieve your compensation goals while supporting a great work / life balance.
Conditions of Employment
- Background investigations are required for all positions at CytomX, consistent with applicable law.
CytomX’s Commitment to Diversity, Equity, Inclusion, and Belonging (DEIB)
CytomX believes that DEIB helps drive our success, and we encourage candidates from all identities, backgrounds, and abilities to apply. We are an equal opportunity employer committed to building an inclusive, innovative work environment with employees who reflect our values and ultimately, serve our patients. Therefore, in all aspects of the employment process, we provide employment opportunities to all qualified applicants without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity or expression, pregnancy, medical condition related to pregnancy, creed, ancestry, national origin, marital status, genetic information, or military status, or any other protected status in accordance with applicable law.
Further, we are committed to the full inclusion of all qualified individuals. As part of this commitment, we (and the agencies we work with) will assist individuals who have a disability with any reasonable accommodation requests related to employment, including completing the application process, interviewing, completing any pre-employment testing, participating in the employee selection process, and/or to perform essential job functions where the requested accommodation does not impose an undue hardship. If you have a disability and require reasonable accommodation, or need other assistance in applying for or interviewing for this position, please direct your inquiries to Human Resources, at [email protected]
Notice to Recruiters/Staffing Agencies
Recruiters and staffing agencies should not contact CytomX Therapeutics through this page. We require that all Recruitment Vendors (e.g., search firms, recruitment agencies and staffing companies) have a fully executed, formal written agreement on file with CytomX prior to submitting candidates. Any resumes submitted through the website or directly by Recruitment Vendors will be considered unsolicited. Unsolicited vendor submissions do not constitute any actual or implied contract with CytomX, and CytomX will not be responsible for any purported fees. For more information, please contact our HR team at [email protected]
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