Buck Institute for Research on Aging Careers

Description

Eye Aging and Neurodegeneration using Flies and Mammals

POSITION SUMMARY

The focus of the Kapahi Laboratory is to identify and characterize the mechanisms by which nutrients modulate aging and age-related diseases. This is being achieved by using an interdisciplinary approach combining genetic, pharmacological, biochemical, and genomic approaches in invertebrate model systems C. elegans, D. melanogaster, and mammalian cells. The broader significance of this research is to help uncover the role of nutrition in the etiology of age-related human diseases like diabetes, obesity, and neurodegeneration. You will join a highly collaborative group and the ability to be a collaborative team member is a key expectation. The position is ideal for candidates who want to transition to academia and write a K99. Strong mentorship and support to write grants will be provided.  

We have openings for 2 Postdoctoral positions that involve using bioinformatic approaches from flies and humans to study the role of circadian clocks and nutrient-responsive pathways influencing eye and neuronal degeneration using flies and conserved orthologs from humans.  

QUALIFICATIONS  

• Previous background in fly or bioinformatics approaches is an advantage but not essential.
• Willingness to write grants and manuscripts is a pre-requisite.

Publications   

1. Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock. Sara Ahadi, Kenneth A Wilson Jr, Boris Babenko, Cory Y McLean, Drew Bryant, Orion Pritchard, Ajay Kumar, Enrique M Carrera, Ricardo Lamy, Jay M Stewart, Avinash Varadarajan, Marc Berndl, Pankaj Kapahi, Ali Bashir. Elife. 2023 Mar 28; https://elifesciences.org/articles/82364

1. Dietary restriction and clock delay eye aging to extend lifespan in melanogaster. Hodge BA, Meyerhof GT, Katewa SD, Lian T, Lau C ,Bar S, Leung NY, Li M, Li-Kroeger D, Melov S, Schilling B, Montell C, Kapahi P. Nat Commun. 2022 Jun 7. https://www.nature.com/articles/s41467-022-30975-4

COMPENSATION & BENEFITS  

• The starting salary for a new postdoc at the Buck is $70,140 in 2024, with a range up to $82,000 commensurate with postdoc level & experience.
• Exciting, dynamic work environment at the forefront of science using state-of-the-art techniques.
• Generous benefits package including health insurance, paid parental leave, childcare assistance, generous vacation/sick leave, and 401(k) with 5% employer match.
• Collaborative and dynamic environment both for science and social activities.

ABOUT THE BUCK INSTITUTE  

Our success will ultimately change healthcare. At the Buck, we aim to end the threat of age-related diseases for this and future generations by bringing together the most capable and passionate scientists from a broad range of disciplines to identify and impede how we age. We are an independent, non-profit institution located in Marin County, CA, to increase human health span or the healthy years of life. Globally recognized as the pioneer and leader in efforts to target aging—the number one risk factor for diseases including Alzheimer’s, Parkinson’s, cancer, macular degeneration, heart disease, and diabetes—the Buck seeks to help people live better longer.  

We are an equal opportunity employer and strive to create an atmosphere where diversity of identity, experience, and background are welcomed, valued, and supported. Candidates who contribute to this diversity are strongly encouraged to apply.  

TO APPLY  

Interested candidates should apply online and upload a CV and cover letter including contact information for 3 professional references.  

For questions regarding this position, please email [email protected] or visit https://www.buckinstitute.org/lab/kapahi-lab/